Endocrine Abstracts

Introduction: There has recently been a suggested link between central adrenal insufficiency and the high rate of sudden death in children and adolescents with Prader–Willi syndrome (PWS). This finding has important implications for PWS management, since steroid cover could exacerbate the existing tendency towards obesity. We have retrospectively examined our data for both mortality and pituitary–adrenal axis status in subjects attending the dedicated PWS clinic at t...

Background: Hyperthyroidism is a significant medical condition in paediatric patients with serious health consequences. Optimal treatment remains debatable.Objective: To review 23 years’ experience of paediatric hyperthyroidism in the West of Scotland.Methods: Case notes of patients treated for thyrotoxicosis in Glasgow, Paisley, Ayrshire and Lanarkshire from 1987 until 2009 inclusive were retrospectively reviewed. Patients wi...

Background: Small for gestational age (SGA) and short stature at birth can be defined as birth weight (BW) and birth length (BL) ≤−2 S.D.. Affected neonates can be classified as: i) SGA, ii) Short, iii) SGA + Short. Catch-up growth occurs by age 6 months in 90–95% of Short and SGA + Short infants. A minority remain short after age 2–4 years when the lack of data on BL and parental height (PH) renders assessment difficult.<p class="abste...

The UK Turner Study examined in girls with Turner syndrome (TS) the impact on final height (FH) of Oxandrolone (Ox) and/or delayed pubertal induction (14y).Methods: Girls with TS aged 7–13y receiving GH were randomised to Ox (0.05 mg/kg per day, max. dose 2.5 mg/day) or placebo from 9y (or from enrolment if >9y). Girls requiring oestrogen were further randomised to begin oral Ethinylestradiol (E2) (Y1:2 μg/day; Y2:4 μg/day; ...